Hello! I have a bulldog mix (75% English, 25% American) and we've been unable to get a diagnosis for her symptoms. She started having episodes of heavy panting and trembling back in late spring, early summer, but they were infrequent and short. They also only seemed to occur in the evening hours of about 7 p.m. to 9 p.m., which was typically when she'd be the most alert/active/happy. Slowly over time they became more frequent and longer. My vet at first thought she was in pain, and prescribed a pain pill, but the pain pill didn't seem to touch it- she continued to pant/tremble. He then considered anxiety/dementia/sundowners, so he prescribed trazadone and gabapentin to try. Neither of those seemed to help, and she also got ataxia (not able to walk) when taking the gabapentin. She's had a urine test, blood test, ekg, echocardiogram, and chest xray. There appears to be no heart issue and she doesn't have Addison's. She's now scheduled for a cushing's test next week, but I'm scared because this past Wednesday she had the panting/trembling all day, off and on but mostly on, until I finally took her to the emergency vet at 3 a.m. Again, no diagnosis, but he did give a muscle relaxer/pain pill/anti-anxiety combo that seemed to work. She was fine but not herself all day yesterday, and slept last night, but woke up panting and not wanting to eat this morning. I gave her the 3-pill combo again, but I'm scared that she might not make it to the cushing's test next week, or that she will make it but it won't reveal a diagnosis. Has anyone had this type of trajectory of symptoms in their pet before? The first episodes a few months ago were about 5-10 mins, and sometimes accompanied by frantic behavior such as humping, licking, chewing bully sticks aggressively, and sometimes even barking (she's not a barker normally). And these behaviors were also performed looking right at me, as if she were trying to tell me something she needed. The new, longer episodes are less manic- just labored panting and trembling. It's almost like she's worn out from it at this point. Anyone thoughts whatsoever are very very appreciated! I think she has some of the cushing's symptoms, but other aspects make me think not.