Amputation should be a last resort. What are you feeding your EB? I know that Desertskybulldogs has recomended in the past Panagol(not sure if I spelled it right) but you need a prescription for it. This might be an infection and you might need to go to your vet to make sure. What I do with Mocha is clean once a day (usually at nite) with Malacetic wipes and then dry the area very well and then I apply Golds Bond powder( the yellow bottle) on dry her tail to keep it dry. You should put a little bacitracin on it or Goodwinol ointment in the mean time before you get see your vet.