I think it might be wise to address the wrinkles. I'm thinking the wipes and tissues are not working. This does not mean you must purchase expensive items to clean the wrinkles.
I use diluted medicated soap.
Amazon.com: Vet Solutions Surgical Scrub & Handwash, 16oz. Refill Bottle: Everything Else
If you mix some up you can store it in a picnic ketchup container. The nozzle makes it great for application. Which I use cotton pads or...cotton balls when I can't locate the pads. You can warm up the bottle in the microwave so it's warm...my bullie prefers it that way. Apply some on the cotton pad and wipe area...then use a clean dry pad to dry the area.
On really nasty sore wrinkles. I have used Pinxav...but be careful not to get it into their eyes...Use it sparingly...this stuff will stain clothing. But if your bullie has sore wrinkles...it will help sooth them. And heals them up lickity split.
As for hot spots...this stuff works great full strength rubbed in until you no longer see it. We're talking no oral medication needed this stuff clears it up so quickly!!! [Tank my oldest used to get them...hasn't had any in so long...but we love this stuff and use it for so many things and was the original reason the VET solutions surgical scrub was brought into the house.]