I had 3 dogs on apoquel. The first one had allergies so bad he could barely function...he was a lab mix. It was a miracle for him. He was on it a year before he passed...he was pretty old. Then I had my Boston Terrier and Yorkie on it. Both on it for around a year. It messed up their immune systems bad. Both ended up getting fungal infections, ear infections, hair loss, a bloated look to bellies and stomach issues. It does take care of allergies, just use it sparingly. My dogs were on it everyday for almost a year...not good. I will always wonder if it contributed to the death of my Lab...probably so.