Yes- that's what happened with Blue. Took him to our vet and she said sprain, took him to our specialist and she said infection. Put him on antibiotics for 3 weeks, cleaned him out and told us to use mal-a-ket wipes twice a day. That's what we did and a few days into it he was fine again.
It took two of us to clean him though. Chris would hold him like they do at the vets (where the dogs stand and the vet tech has one arm across the chest and the other under), while I cleaned his pocket.