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Thread: Trifexis vs Sentinel

  1. #1
    Rescue Volunteer Rural mystic's Avatar
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    Default Trifexis vs Sentinel

    I know that this issue has been discussed quite a bit but here I go again.
    Since Ace started heartworm preventative treatment I have been using Trifexis with no serious side effects. Other than perhaps a little lethargy after the first usage all has gone well. I resisted changing to Sentinel because Ace seemed to be doing well on Trifexis and it is what our Vet recommended and I was reluctant to change also because of the fear that he might have a negative reaction to Sentinel so I felt caught between a rock and a hard place. Like many others here I have had my concerns and have spent quite a bit of time researching both medications and the active ingredients in both. They both use milbermycin oxime for heartworm prevention the difference in the medications as far as the type of chemical used is in the flea and tick medication. Trifexis uses spinosad and Sentinel uses lufenuron. Each time I visited the Vet and it was time for heartworm medication I raised my concerns and each time was given reassurance that Trifexis was safe and etc and also kills the adult fleas vs only the flea larvae as Sentinel does. But each time I gave the treatment it was with fear and trembling and reservation. In the last couple of weeks, it being the time for treatment, I had Ace weighed and he was at 65 pounds so now He was prescribed the largest dose of Trifexis. He was on the 40-60 pound dose now up to the 60+ to 120 pound dose. This really bothered me. If a dose with a range of 20 pounds and the dog at the high end of weight was sufficient then at the 60+weight range, Ace being 65 he would be taking a dose that would treat a dog up to 120 pounds, that is practically double the weight and so the medication would have to be sufficient for the higher weight dog which gave me quite a bit of concern for Ace that just barely fit into that category. I got the medication but wouldn't give it and decided I would split the dose if I couldn't get the lower dose or seek another alternative. I didn't talk with the Vet this time but the personnel there said they couldn't give the lower weight range dosage as it wouldn't be sufficient. After doing more research, basically the same results as before, but one thing I have noticed during all this time was that the anecdotal comments on all the sites I visited range from about 60 to 70 percent or higher with negative comments and warnings on the Trifexis, it may not be scientific but for me its not something to dismiss out of hand. So anyway I am changing to Sentinel. The dose for Ace with Sentinel is in the 50-100 pound range, still significant but better in my opinion as Ace would be at about the median to higher end of weight for the amount of medication he would be taking. I had to jump through hoops to get it.? The Vet did not carry it on hand at the clinic and I had to go online through their prescription website to order it and it will be mailed to my home.
    Last edited by Rural mystic; 07-29-2013 at 06:15 PM.

  2. #2
    Texas Carol....put the heart in EBN Become a 4 Paw Member
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    Default Re: Trifexis vs Sentinel

    Yea for you Tim, for being proactive and thinking it thru...I agree, for a 5 lb
    difference, I'd stay on the same dosage NOT go to a 55 lb difference, crazy!


    My 1st bully, Brutus
    RIP beloved boy.

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    Default Re: Trifexis vs Sentinel

    Tim..I know how much you worried about this..that's what we do. I commend you for following your gut. Ace is a very lucky Bully indeed..

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    Dog Park Attendant TomVan's Avatar
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    Default Re: Trifexis vs Sentinel

    I agree, that would be very scary giving a 65 pound dog a med that would be the same for a 120 pound dog. I feel you made the right move.
    Every once in a while a dog enters your life and changes everything.


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    Default Re: Trifexis vs Sentinel

    You have put a lot of thought and research into your decision I too have been doing the research and talking to the vet about the positives versus the negatives of Trifexis like you though Sheldon would fall into that higher category because he is about 65lbs as well its all about the decisions we make for our fur babies....its tough to decide what is the best when you have this person and that person buzzing in your ear like mosquitoes....

    R.I.P. Duece Man 9-13-14 Gone but not forgotten, always in our hearts! Till we meet again over the Bridge, Mommy misses you.

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    Default Re: Trifexis vs Sentinel

    Please let me know how Ace does as this is a decision I have been struggling with myself.

    R.I.P. Duece Man 9-13-14 Gone but not forgotten, always in our hearts! Till we meet again over the Bridge, Mommy misses you.

  7. #7
    Rescue Volunteer Rural mystic's Avatar
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    Default Re: Trifexis vs Sentinel

    Quote Originally Posted by Jennifer Clark View Post
    You have put a lot of thought and research into your decision I too have been doing the research and talking to the vet about the positives versus the negatives of Trifexis like you though Sheldon would fall into that higher category because he is about 65lbs as well its all about the decisions we make for our fur babies....its tough to decide what is the best when you have this person and that person buzzing in your ear like mosquitoes....
    I agree. I ordered one dose and will give the Sentinel with trepidation too. But if Ace does well on it, with little or no side effects, then if I don't have any problems with fleas I will probably stay with the Sentinel. We shall see. As the heartworm chemical is the same in both products I researched the different chemicals that are used in the products for fleas. Still its a mixed bag with both seemingly safe although perhaps a bit better with the lufenuron that is in Sentinel. But that chemical does not kill adult fleas so that has to be considered too. It sort of boils down to the flea and tick medication as the other chemical is the same in both. It's not an easy choice, especially as Ace has really never had a problem with Trifexis. But this big jump in dosage was disconcerting to say the least. Such is the power of persuasion. If all in this forum swore by Trifexis and if the anecdotal comments in other forums were even steven then I probably would have stayed with Trifexis. In actuality, and I know this with my head but my heart is troubling me, they both may be as safe, as effective and as dangerous as the other

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    Default Re: Trifexis vs Sentinel

    My sweet Steve lost his life to trifexis

  9. #9
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    Default Re: Trifexis vs Sentinel

    I was a little uncomfortable with Sheldon's reaction yesterday to the Comfortis this is his third month on it and I gave him his dose night before last and all day yesterday he refused to eat and was very lethargic I did everything I could do even pulled out the special treats and he didn't want any of it but today he is fine

    R.I.P. Duece Man 9-13-14 Gone but not forgotten, always in our hearts! Till we meet again over the Bridge, Mommy misses you.

  10. #10
    Rescue Volunteer Rural mystic's Avatar
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    Default Re: Trifexis vs Sentinel

    Quote Originally Posted by Diane Brizendine Slocum View Post
    My sweet Steve lost his life to trifexis
    My condolences. All parasite and pesticide medications are worrisome. We all do the best we can with the information we recieve. Hindsight is 20-20. You had no way of knowing in advance and probably acted in good faith. So sorry for the loss.

  11. #11
    Bulldog Walker Starkie's Avatar
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    Default Re: Trifexis vs Sentinel

    Didn't someone here say Trifexis doesn't prevent/treat ticks? We checked the package and it does not mention ticks.

    Just curious if Sentinel prevents/treats ticks? That could be a reason for us to switch and avoid the cost of Advantix for ticks.

    Speaking of costs, and we would never do it just to save money, but was the presciption website cheaper for Sentinel than getting Trifexis from the local vet?

  12. #12
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    Default Re: Trifexis vs Sentinel

    Quote Originally Posted by Starkie View Post
    Didn't someone here say Trifexis doesn't prevent/treat ticks? We checked the package and it does not mention ticks.

    Just curious if Sentinel prevents/treats ticks? That could be a reason for us to switch and avoid the cost of Advantix for ticks.

    Speaking of costs, and we would never do it just to save money, but was the presciption website cheaper for Sentinel than getting Trifexis from the local vet?
    Trifexis and Sentenial does not prevent or treat for ticks only fleas. You can use a topical for tick prevention in addition to Tifexis or Sentenial but IMO that is a lot of peticides. If Ticks is a major concern I would use Heartguard with K9 Advantix II or Frontiline Plus

    My vet also try to push trifexis but I personally think they get a kick back from the manufacture. I never buy prescriptions from the vet I find they are less expensive at 1-800-pet-med they usually have a coupon for percent off. Costco and Sams club now sells pet meds with a presription and they are a few dollars cheaper then the web sites. If you do buy from a web site make sure they are legitimate company I have heard some scary stories of fake meds made in china. If the price seems too good to be true dont buy it.
    Last edited by Ashleym; 07-29-2013 at 04:02 PM.

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