we used Rimadyl short term for our mix, as far as supplements we had our rescue St. Bernard on glucosamine from basicly day one. he had bad hips, but there was nothing they could do for him due to his age and health. I never saw anything dramatic as far as changes went for him, I did notice them helping as he would walk longer, and get up easier. But as far as the supplement, it takes a awhile and the change will not be overnight. at least that is my experience.