ABEBD
New member
- Feb 18, 2011
- 747
- 78
- Country
- U.S.A.
- Bulldog(s) Names
- By many names depending on the situation?
Hello,
I have a male 2.5 yo that has recently been through two major surgeries related to Cystine stones/crystals. I add the slash because the crystals are the same as the stones but in different stages.
As a result, I need to have my other Bullies tested to see if they are free or are a carrier.
Here is some brief information about the problem;
Testing for Hyperuricosuria
Hyperuricosuria is characterized by the excretion of uric acid leading to urate stone formation. After the defective gene that causes hyperuricosuria was discovered by researchers at the University of California, Davis, a test was developed to detect the mutation associated with the disease. This test is valid for all breeds.
Dogs affected by hyperuricosuria have two copies of the mutation, one inherited from each parent. Dogs with only one copy of the mutation are symptom-free carriers who pass the mutation on to an average of 50 percent of their offspring. Breeders can use DNA testing to identify carriers and effectively eradicate hyperuricosuria from their lines in breeds other than Dalmatians. (At present, all Dalmatians registered by the American Kennel Club in the United States are affected by the mutation. When both dam and sire are clear of the mutation, all of their puppies will be clear as well.
The DNA test identifies dogs in three categories: clear of hyperuricosuria (the dog has two copies of the normal gene and no mutation), a carrier of hyperuricosuria (the dog has one copy of the normal gene and one of the mutation), or affected with hyperuricosuria (the dog has two copies of the mutation, causing high uric acid levels that can lead to urate stone disorders).
All dogs affected with hyperuricosuria are potential urate stone-formers. At any time, a combination of high-purine foods, insufficient fluids, insufficient opportunities to urinate, and overly acidic urine might cause the formation of urate uroliths. Periodic routine urinalysis to check for urate crystals can be used to monitor dogs with hyperuricosuria. The most accurate sample for this purpose is collected in the morning, assuming the dog has not urinated all night, so the urine is more concentrated. The sample should be collected in a clean glass, plastic, or other chemically inert container. To avoid false crystallization, the sample should not be refrigerated and should be tested within 30 minutes or as soon as possible.
Urolithiasis (Cystine) in Dogs
Urolithiasis is a medical term referring to the presence of crystals or stones in the urinary tract. When the stones are made up of cystine – a normal compound found in the body – they are called cystine stones. These stones can also be found in the kidneys and in the tubes connecting the kidneys to the animal's bladder (ureters).
Urolithiasis affects both dogs and cats, and are primarily found in adult animals. As far as dogs breeds: Dachshunds, English Bulldogs, Newfoundlands, Staffordshire Bull Terriers, and Welsh Corgi Dogs are more susceptible to cystine stones.
Ultrasounds and X-rays are often performed to determine the size, shape, and location of the stones, helping the veterinarian come up with an appropriate treatment regimen. A urine test can also detect the presence of stones.
Since regular x-rays can detect these “special” kinds of stones/crystals, a dye is added to the bladder and then they show up in reverse contrast on an x-ray.
This is costly to have these emergency surgeries. Better to find out in advance and take precautions to prevent.
Good Day~
I have a male 2.5 yo that has recently been through two major surgeries related to Cystine stones/crystals. I add the slash because the crystals are the same as the stones but in different stages.
As a result, I need to have my other Bullies tested to see if they are free or are a carrier.
Here is some brief information about the problem;
Testing for Hyperuricosuria
Hyperuricosuria is characterized by the excretion of uric acid leading to urate stone formation. After the defective gene that causes hyperuricosuria was discovered by researchers at the University of California, Davis, a test was developed to detect the mutation associated with the disease. This test is valid for all breeds.
Dogs affected by hyperuricosuria have two copies of the mutation, one inherited from each parent. Dogs with only one copy of the mutation are symptom-free carriers who pass the mutation on to an average of 50 percent of their offspring. Breeders can use DNA testing to identify carriers and effectively eradicate hyperuricosuria from their lines in breeds other than Dalmatians. (At present, all Dalmatians registered by the American Kennel Club in the United States are affected by the mutation. When both dam and sire are clear of the mutation, all of their puppies will be clear as well.
The DNA test identifies dogs in three categories: clear of hyperuricosuria (the dog has two copies of the normal gene and no mutation), a carrier of hyperuricosuria (the dog has one copy of the normal gene and one of the mutation), or affected with hyperuricosuria (the dog has two copies of the mutation, causing high uric acid levels that can lead to urate stone disorders).
All dogs affected with hyperuricosuria are potential urate stone-formers. At any time, a combination of high-purine foods, insufficient fluids, insufficient opportunities to urinate, and overly acidic urine might cause the formation of urate uroliths. Periodic routine urinalysis to check for urate crystals can be used to monitor dogs with hyperuricosuria. The most accurate sample for this purpose is collected in the morning, assuming the dog has not urinated all night, so the urine is more concentrated. The sample should be collected in a clean glass, plastic, or other chemically inert container. To avoid false crystallization, the sample should not be refrigerated and should be tested within 30 minutes or as soon as possible.
Urolithiasis (Cystine) in Dogs
Urolithiasis is a medical term referring to the presence of crystals or stones in the urinary tract. When the stones are made up of cystine – a normal compound found in the body – they are called cystine stones. These stones can also be found in the kidneys and in the tubes connecting the kidneys to the animal's bladder (ureters).
Urolithiasis affects both dogs and cats, and are primarily found in adult animals. As far as dogs breeds: Dachshunds, English Bulldogs, Newfoundlands, Staffordshire Bull Terriers, and Welsh Corgi Dogs are more susceptible to cystine stones.
Ultrasounds and X-rays are often performed to determine the size, shape, and location of the stones, helping the veterinarian come up with an appropriate treatment regimen. A urine test can also detect the presence of stones.
Since regular x-rays can detect these “special” kinds of stones/crystals, a dye is added to the bladder and then they show up in reverse contrast on an x-ray.
This is costly to have these emergency surgeries. Better to find out in advance and take precautions to prevent.
Good Day~
