well the puffiness between the toes is allergies I believe. Miila has had that on and off since we got her. She too gets the interdigital cysts but even when not, she tends to have that puffiness. When we first got her it was really bad. Now her paws are MUCH beter but I do see it flare up depending on how much she is itching so you may wanna try a diff food. The staining doesnt wash off in the folds if that is what you are referring to. Red in the folds like irritation or red like staining? Some people figure out what food works for their babies to not have stains and some never do. If there are beets in the food you feed or treats that can cause staining. Cutty had stains for years and since being on fromm they are gone thankfully.