Yes, my boy Finn had his tail amputation in January 2014. He had about 3/4 of his corkscrew tail removed b/c of recurrent tail infections. Finn had the surgery done by his regular vet and I was able to take him home the same day. He was on some heavy pain meds--a fentanyl patch, rimadyl and tramadol. I recall the first several nights post-op of sleeping on the floor w/him b/c he wasn't supposed to do any jumping or too much activity. I think he started becoming his old self again after 2 or 3 days. Luckily, he healed up pretty well and w/no complications.
Talk to your vet with your concerns and worries. Tail amputation is a fairly common surgery with EB's but i know i was a huge worry-wart about it too. Best of luck to you and Hugo. I know he will do just fine.