Hi Becky. So sorry you're going through this with your guy ( Sorry I don't know his name?). I'm sorry he's having such a hard time. Are the foods you've been feeding him chicken based? Do they contain corn or grains? These are things that many EB's are sensitive or allergic to. My female Blossom is allergic to chicken, salmon, corn, and grains. We feed our guys Fromm's Lamb and Lentil. It seems you are doing all the right things, giving Zyrtec, probiotics, and omegas. It could also be the omega. I had to stop giving blossom salmon oil because she was allergic to it. I switched my guys to Coconut Oil. Have you given her any new treats? Do you buy store bought treats, many of these have grains, chemicals, and lots of preservatives. If its to diet related, it could also be something new in the environment such as new laundry soap, cleaner, or shampoo? And it can also be from environmental causes like grass, or a bug bite. You can have her tested for allergies to know for sure. It can be frustrating trying to figure out what the cause is, and it's trial and error, and elimination or going totally back to basics, and then reintroducing one thing at a time, to see what causes a reaction. I hope you are able to figure out what is causing the allergic reactions, and she feels better soon.