Hi, it's always a big worry for how our bully's are going to cope without us, and with a different routine than what they're used to. It basically comes down to your dogs personalities, and how they adapt and socialize to different situations, and to who you trust and feel comfortable with taking care of them. If your friend house sits with them at your house, then they are in familiar surroundings, and less likely to be stressed, they will have their regular routines, and familiar scenes, and beds. If you trust your friend, then this would be a good choice. Maybe you could try a trial night with your friend at the house before you go away, and see how she copes. Boarding them with your vet is also a good choice, as they would be in the care of a vet, medication and skin issues would be taken care of by an experienced vet, and his staff. But they would be out of their home and familiar surroundings. If you think they would be able to handle this without being stressed or scared then it is also a good option. Another option would be to let your friend babysit with Ellie, as she seems to be the one who would be more stressed and scared being in a strange place, and the vet can take care of Jagger, that way your friend would only have to take care of one and it might be easier for her to handle. That way both of them would be in good hands. I hope you find a solution that works for everyone, and you can travel without being too worried. I'm sure what ever you choose they will be in good hands either way, and they will be okay and adapt. Both options would leave them in responsible care. I hope you have a good visit, and I'm so sorry your niece is going through this, it must be very scary. I hope she handles and tolerates treatment okay, and feels better and beats this soon. Sending her love , hugs, and prayers her way.