Not sure if I have the answers to this but the only concern I would think would be dog socialization, and making sure the pup has plenty of human interaction while young. Nutrients and such depend much on if nursing and what food they use once weened. In the womb yes it would be a benefit. Lots of room and all the nutrients given, provided the mother was fed properly. See a lot of it depends on how the owners care for the mom and pup essentially.
I will move this to the breeders area for more people with exp in this area